The Red Sox clinched a series victory after topping the White Sox 4-2 in their finale from Fenway Park.
Walker Buehler collected the win after striking out nine while allowing one run over seven innings.
Rob Refsnyder went deep with a solo shot for his first home run of the season.
Boston has won five of its last six games.
Jonathan Cannon suffered the loss after allowing four runs on six hits and four walks.
Chicago has dropped seven of its last eight.
The Red Sox host the Mariners tonight.
(Photo By Winslow Townson/Getty Images)
Photo: Winslow Townson / Getty Images Sport / Getty Images